[HTML][HTML] HER2 status in breast cancer: changes in guidelines and complicating factors for interpretation
S Ahn, JW Woo, K Lee, SY Park - Journal of pathology and …, 2020 - synapse.koreamed.org
Human epidermal growth factor receptor 2 (HER2) protein overexpression and/or HER2
gene amplification is found in about 20% of invasive breast cancers. It is a sole predictive …
gene amplification is found in about 20% of invasive breast cancers. It is a sole predictive …
Clinical management of breast cancer heterogeneity
Traditionally, intertumour heterogeneity in breast cancer has been documented in terms of
different histological subtypes, treatment sensitivity profiles, and clinical outcomes among …
different histological subtypes, treatment sensitivity profiles, and clinical outcomes among …
Receptor conversion in distant breast cancer metastases: a systematic review and meta-analysis
WAME Schrijver, KPM Suijkerbuijk… - JNCI: Journal of the …, 2018 - academic.oup.com
Background In metastatic breast cancer, hormone and/or human epidermal growth factor
receptor 2 (HER2)–targeted therapy decision-making is still largely based on tissue …
receptor 2 (HER2)–targeted therapy decision-making is still largely based on tissue …
Somatic mutation of CDKN1B in small intestine neuroendocrine tumors
The diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing,
and the underlying genomic mechanisms have not yet been defined. Using exome-and …
and the underlying genomic mechanisms have not yet been defined. Using exome-and …
Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients
A Babayan, J Hannemann, J Spoetter, V Mueller… - PloS one, 2013 - journals.plos.org
Background Endocrine treatment is the most preferable systemic treatment in metastatic
breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or …
breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or …
Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer …
Background The expression of HER2, estrogen (ER) and progesterone (PR) receptor can
change during the course of the disease in breast cancer (BC). Therefore, reassessment of …
change during the course of the disease in breast cancer (BC). Therefore, reassessment of …
Stereotactic radiosurgery with concurrent lapatinib is associated with improved local control for HER2-positive breast cancer brain metastases
OBJECTIVE With increasing survival for patients with human epidermal growth factor
receptor 2-positive (HER2+) breast cancer in the trastuzumab era, there is an increased risk …
receptor 2-positive (HER2+) breast cancer in the trastuzumab era, there is an increased risk …
Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1
Transcriptional regulation of ESR1, the gene that encodes for estrogen receptor α (ER), is
critical for regulating the downstream effects of the estrogen signaling pathway in breast …
critical for regulating the downstream effects of the estrogen signaling pathway in breast …
Systematic review and meta-analysis of breast cancer brain metastasis and primary tumor receptor expression discordance
Background Change in hormone receptor (estrogen [ER] and progesterone [PR]) and/or
human epidermal growth factor receptor type 2 (HER2) status during the evolutionary course …
human epidermal growth factor receptor type 2 (HER2) status during the evolutionary course …
Association of biomarker discrepancy and treatment decision, disease outcome in recurrent/metastatic breast cancer patients
Y Lu, Y Tong, X Chen, K Shen - Frontiers in oncology, 2021 - frontiersin.org
Background Biomarker discrepancy between primary and recurrent/metastatic breast cancer
is well known, however its impact on prognosis and treatment after relapse is still unclear …
is well known, however its impact on prognosis and treatment after relapse is still unclear …