Randomization in clinical trials is the key design technique to ensure the comparability of
treatment groups. Although there exist a large number of software products which assist the …

Adaptive designs are increasingly developed and used to improve all phases of clinical
trials and in biomedical studies in various ways to address different statistical issues. We first …

This study investigated the effect of overnight sleep on associative novel word learning and
examined whether the effects of sleep on word learning are modulated by the provision of …

Recent studies show positive effects of acute exercise on language learning in young adults
with lower baseline learning abilities; however, this is yet to be investigated in older adults …

Adaptive designs are increasingly used in clinical research to improve flexibility and
efficiency of clinical trials. Adaptive designs allow a trial to make prespecified changes …

This study investigated the effect of sleep on novel word learning through reading context.
Seventy-four healthy young adults attended two testing sessions, with either overnight sleep …

We consider optimal design problems for dose-finding studies with censored Weibull time-to-
event outcomes. Locally D-optimal designs are investigated for a quadratic dose–response …

Randomization is an important technique in research because, when accomplished
successfully, it not only removes potential personal bias from research but also removes …

Background and objective Binary response models are used in many real applications. For
these models the Fisher information matrix (FIM) is proportional to the FIM of a weighted …

Background: This manuscript is a guide to help students in their preparation to design a
clinical study. Randomized clinical trials are required to investigate different therapeutic …