Amide bond bioisosteres: Strategies, synthesis, and successes

S Kumari, AV Carmona, AK Tiwari… - Journal of medicinal …, 2020 - ACS Publications
The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Insights on the use of α-lipoic acid for therapeutic purposes

B Salehi, Y Berkay Yılmaz, G Antika… - Biomolecules, 2019 - mdpi.com
α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants,
animals, and humans. It has various properties, among them great antioxidant potential and …

The relationship between nutrition and the immune system

C Munteanu, B Schwartz - Frontiers in nutrition, 2022 - frontiersin.org
Nutrition plays an essential role in the regulation of optimal immunological response, by
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …

Molecular and therapeutic insights of alpha-lipoic acid as a potential molecule for disease prevention

AK Tripathi, AK Ray, SK Mishra, SM Bishen… - Revista Brasileira de …, 2023 - Springer
Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and
animals. As a potent antioxidant and a natural dithiol compound, it performs a crucial role in …

Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells

MM Suhail, W Wu, A Cao, FG Mondalek… - … and alternative medicine, 2011 - Springer
Background Gum resins obtained from trees of the Burseraceae family (Boswellia sp.) are
important ingredients in incense and perfumes. Extracts prepared from Boswellia sp. gum …

An overview of the antioxidant effects of ascorbic acid and alpha lipoic acid (in liposomal forms) as adjuvant in cancer treatment

M Attia, EA Essa, RM Zaki, AA Elkordy - Antioxidants, 2020 - mdpi.com
Antioxidants are known to minimize oxidative stress by interacting with free radicals
produced as a result of cell aerobic reactions. Oxidative stress has long been linked to many …

The disulfide compound α-lipoic acid and its derivatives: a novel class of anticancer agents targeting mitochondria

B Dörsam, J Fahrer - Cancer letters, 2016 - Elsevier
The endogenous disulfide α-lipoic acid (LA) is an essential mitochondrial co-factor. In
addition, LA and its reduced counterpart dihydro lipoic acid form a potent redox couple with …

[HTML][HTML] Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention

S Roy, AK Rawat, SR Sammi, U Devi, M Singh… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Alpha linolenic acid is an essential polyunsaturated fatty acid and is reported to have the
anti-cancer potential with no defined hypothesis or mechanism/s. Henceforth present study …

Review of lipoic acid: from a clinical therapeutic agent to various emerging biomaterials

S Lv, S He, X Ling, Y Wang, C Huang, J Long… - International Journal of …, 2022 - Elsevier
Lipoic acid (LA), an endogenous small molecule in organisms, has been extensively used
for the highly efficient clinical treatment of malignant diseases, which include diabetes …

Implications of dietary ω‑3 and ω‑6 polyunsaturated fatty acids in breast cancer

O Zanoaga, A Jurj, L Raduly… - Experimental and …, 2018 - spandidos-publications.com
Breast cancer represents one of the most common forms of cancer in women worldwide,
with an increase in the number of newly diagnosed patients in the last decade. The role of …