This Review explores the evolution, improvements, and recent applications of Light Sheet
Fluorescence Microscopy (LSFM) in biological research using a high numerical aperture …

Animals use information about gravity and other destabilizing forces to balance and
navigate through their environment. Measuring how brains respond to these forces requires …

We present a combination of light-sheet excitation and two-dimensional fluorescence
intensity ratio (FIR) measurements as a simple and promising technique for three …

Calcium (Ca2+) imaging has been largely used to examine neuronal activity, but it is
becoming increasingly clear that subcellular Ca2+ handling is a crucial component of …

Animals must maintain their balance to navigate in their environment effectively. As animals
mature, their ability to correct their posture improves. Postural reflexes are driven by a …

The research motivation for this thesis was the design, construction, and operation of a Light-
sheet Fluorescent Microscope (LSFM) that is capable of imaging freely moving whole …