Systemic lupus erythematosus (SLE), an autoimmune disease, develops when immunologic
self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by …

Regulatory T (Treg) cells are a subset of CD 4+ T cells that are critical for the maintenance of
self‐tolerance. The forkhead box transcription factor Foxp3 is a master regulator for the Treg …

Abstract Introduction Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with
immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit …

The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs. We
previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios …

Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects
of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor …

Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach;
however, it has shown limited success in some cancers including colorectal cancer (CRC) …

Helios transcription factor and semaphorin receptor Nrp-1 were originally described as
constitutively expressed at high levels on CD4+ Foxp3+ T regulatory cells of intrathymic …

Regulatory T (Treg) cell modulation of adaptive immunity and tissue homeostasis is well
described; however, less is known about Treg cell-mediated regulation of the innate immune …

The role of T-helper type 17 (Th17) responses in airway remodeling in asthma is currently
unknown. We demonstrate that both parenteral and mucosal allergen sensitization, followed …

Lymphocyte Activation Gene–3 (LAG-3) is an immune checkpoint molecule that regulates
both T-cell activation and homeostasis. However, the molecular mechanisms underlying …