This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Type 2 diabetes continues to negatively impact the health of millions. The inability to
respond to insulin to clear blood glucose (insulin resistance) is a key pathogenic driver of …

It is estimated that> 2 million patients are living with an amputation in the United States.
Peripheral artery disease (PAD) and diabetes mellitus account for the majority of …

Prevalence of sarcopenia is high in patients with chronic kidney disease (CKD), especially
in those with dialysis. Various pathological conditions related to CKD, such as chronic …

Physical activity, together with diet and pharmacological therapy, represents one of the three
cornerstones in type 2 diabetes mellitus treatment and care. The therapeutic appeal of …

Skeletal muscle (SM) tissue has been repetitively shown to play a major role in whole-body
glucose homeostasis and overall metabolic health. Hence, SM hypertrophy through …

Abstract Aims Advanced glycation endproducts (AGEs) are sugar-modified adducts which
arise during non-enzymatic glycoxidative stress. These compounds may become …

Endothelium, acting as a barrier, protects tissues against factors that provoke insulin
resistance and type 2 diabetes and itself responds to the insult of insulin resistance inducers …

The integration of resistance training for cardiac patients leads to important health outcomes
that are not optimally obtained with aerobic exercise; these include an increase in muscle …

There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays
an important role in glucose metabolism by increasing the delivery of glucose and insulin to …