Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
Mechanisms and therapeutic strategies for non‐T2 asthma
E Sze, A Bhalla, P Nair - Allergy, 2020 - Wiley Online Library
Non‐T2 asthma is traditionally defined as asthma without features of T2 asthma. The
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …
Neutrophils: between host defence, immune modulation, and tissue injury
P Kruger, M Saffarzadeh, ANR Weber, N Rieber… - PLoS …, 2015 - journals.plos.org
Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …
European position paper on rhinosinusitis and nasal polyps 2012
WJ Fokkens, VI Lund, J Mullol, C Bachert, I Alobid… - Rhinology, 2012 - biblio.ugent.be
The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …
Leaders in the field were invited to critically appraise the literature and write a report on a …
Extracellular matrix in lung development, homeostasis and disease
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …
Neutrophils in the activation and regulation of innate and adaptive immunity
A Mantovani, MA Cassatella, C Costantini… - Nature reviews …, 2011 - nature.com
Neutrophils have long been viewed as the final effector cells of an acute inflammatory
response, with a primary role in the clearance of extracellular pathogens. However, more …
response, with a primary role in the clearance of extracellular pathogens. However, more …
Neutrophil function: from mechanisms to disease
B Amulic, C Cazalet, GL Hayes… - Annual review of …, 2012 - annualreviews.org
Neutrophils are the most abundant white blood cells in circulation, and patients with
congenital neutrophil deficiencies suffer from severe infections that are often fatal …
congenital neutrophil deficiencies suffer from severe infections that are often fatal …
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
Chronic low-grade adipose tissue and liver inflammation is a major cause of systemic insulin
resistance and is a key component of the low degree of insulin sensitivity that exists in …
resistance and is a key component of the low degree of insulin sensitivity that exists in …
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
JZ Haeggstrom, CD Funk - Chemical reviews, 2011 - ACS Publications
Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …