Recent Advances in Pre-Clinical Development of Adiponectin Receptor Agonist Therapies for Duchenne Muscular Dystrophy

S Gandhi, G Sweeney, CGR Perry - Biomedicines, 2024 - mdpi.com
Duchenne muscular dystrophy (DMD) is caused by genetic mutations in the cytoskeletal-
sarcolemmal anchor protein dystrophin. Repeated cycles of sarcolemmal tearing and repair …

[HTML][HTML] Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway

E Tam, E Song, N Noskovicova, B Hinz, A Xu… - Life Sciences, 2024 - Elsevier
Aims Autophagy is an important cellular process for maintaining physiological homeostasis
and is known to protect against cardiovascular diseases including ischemia reperfusion (I/R) …

[HTML][HTML] A novel blood-based bioassay to monitor adiponectin signaling

AH Lone, J Tang, A Pignalosa, HH Hsu… - International …, 2024 - Elsevier
The diverse beneficial effects of adiponectin-receptor signaling, including its impact on the
regulation of inflammatory processes in vivo, have resulted in development of adiponectin …

Development of a non-invasive bioassay for adiponectin target engagement in mice

J Tang, Y Lei, A Pignalosa, HH Hsu, AA Abdul-Sater… - iScience, 2024 - cell.com
Adiponectin-based therapeutic strategies are promising for managing metabolic diseases
and reducing inflammation, prompting the development of adiponectin receptor agonists …

[HTML][HTML] Cardioprotective Effects of Adiponectin-Stimulated Autophagy

E Tam, M Ouimet, G Sweeney - Journal of Lipid and Atherosclerosis, 2025 - e-jla.org
Cardiovascular diseases (CVDs), including heart failure, pose a significant economic and
health burden worldwide. Current treatment strategies for heart failure are greatly limited, in …