Neutrophils in chronic inflammatory diseases

A Herrero-Cervera, O Soehnlein… - Cellular & molecular …, 2022 - nature.com
Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

Machine learning prediction of antimicrobial peptides

G Wang, II Vaisman, ML van Hoek - Computational peptide science …, 2022 - Springer
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …

[PDF][PDF] Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

M Asai, Y Li, SM Newton, BD Robertson… - FEMS Microbiology …, 2023 - academic.oup.com
Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious
disease models, due to ease of use and the presence of an innate immune system …

Significance of LL‐37 on immunomodulation and disease outcome

B Yang, D Good, T Mosaiab, W Liu, G Ni… - BioMed Research …, 2020 - Wiley Online Library
LL‐37, also called cathelicidin, is an important part of the human immune system, which can
resist various pathogens. A plethora of experiments have demonstrated that it has the …

Expression and function of host defense peptides at inflammation sites

SV Prasad, K Fiedoruk, T Daniluk, E Piktel… - International journal of …, 2019 - mdpi.com
There is a growing interest in the complex role of host defense peptides (HDPs) in the
pathophysiology of several immune-mediated inflammatory diseases. The physicochemical …

LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with …

EY Kim, G Rajasekaran, SY Shin - European journal of medicinal chemistry, 2017 - Elsevier
Abstract KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual
antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We …

Dissecting the relationship between antimicrobial peptides and mesenchymal stem cells

AÉ Silva-Carvalho, MH Cardoso, T Alencar-Silva… - Pharmacology & …, 2022 - Elsevier
Among the various biological properties presented by Mesenchymal Stem Cells (MSCs),
their ability to control the immune response and fight pathogen infection through the …

Antimicrobial peptides as novel anti-tuberculosis therapeutics

JP Silva, R Appelberg, FM Gama - Biotechnology advances, 2016 - Elsevier
Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis,
has recently joined HIV/AIDS as the world's deadliest infectious disease, affecting around …

Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment

JP Silva, C Gonçalves, C Costa, J Sousa… - Journal of Controlled …, 2016 - Elsevier
Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis,
recently joined HIV/AIDS on the top rank of deadliest infectious diseases. Low patient …