Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus
nerve stimulation (tVNS) across basic, translational and clinical research …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Abstract The Locus Coeruleus (LC) and the Substantia Nigra (SN) are small brainstem
nuclei that change with aging and may be involved in the development of various …

Objective To investigate the contribution of substantia nigra (SN) and locus coeruleus (LC)
pathology to clinical signs and symptoms in Parkinson disease (PD) by applying …

Early and profound pathological changes are evident in the locus coeruleus (LC) in
dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor …

Disruptions to dopamine and noradrenergic neurotransmission are noted in several
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …

MRI has been used to develop biomarkers for movement disorders such as Parkinson
disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

Background Parkinson's disease (PD) causes a loss of neuromelanin‐positive,
noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor …

Background The brainstem locus coeruleus (LC) constitutes the intersection of the initial
pathophysiological processes of Alzheimer's disease (AD) and sleep-wake dysregulation in …