The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Metabolic pathways underpin the growth and virulence of intracellular parasites and are
therefore promising antiparasitic targets. The pentose phosphate pathway (PPP) is vital in …

Parasitic trypanosomatids cause important diseases. Dissecting the biochemistry of these
organisms offers a means of discovering targets against which inhibitors may be designed …

The protozoan parasite Leishmania causes leishmaniasis, a neglected tropical disease, that
disproportionately affects underdeveloped countries. This disease has major health …

Antimonials are still the mainstay of treatment against leishmaniasis but drug resistance is
increasing. We carried out short read next‐generation sequencing (NGS) and comparative …

All living organisms depend on NADPH production to feed essential biosyntheses and for
oxidative stress defense. Protozoan parasites such as the sleeping sickness pathogen …

В монографии обобщены современные данные о метаболических механизмах
функционирования клеток иммунной системы при различных иммунопатологических …

Here we report a new polyhydroxylated triterpene, 2β, 6β, 21α-trihydroxyfriedelan-3-one (4)
isolated from the root and stem bark of Dichapetalum albidum A. Chev (Dichapetalaceae) …

Human African trypanosomiasis (HAT, commonly known as African sleeping sickness) is
categorized as a neglected disease, as it afflicts> 50,000 people annually in sub-saharan …