The rates of most paediatric infectious diseases declined during the initial phase of the
COVID-19 pandemic due to the implementation of non-pharmaceutical interventions …

Insufficient development of new antibiotics and the rise in antimicrobial resistance are
putting the world at risk of losing curative medicines against bacterial infection. Quorum …

Since 2022, many countries have reported an upsurge in invasive group A streptococcal
(iGAS) infections. We explored whether changes in Streptococcus pyogenes carriage rates …

At the end of 2022 into early 2023, the UK Health Security Agency reported unusually high
levels of scarlet fever and invasive disease caused by Streptococcus pyogenes (StrepA or …

M1UK is associated with current surges in invasive infection globally, partly due to increased
production of superantigen streptococcal pyrogenic exotoxin A. We show that M1UK is now …

To determine invasive group A Streptococcus trends in Canada, we characterized emm1
isolates collected during 2018–2023. The percentage of hypervirulent M1UK lineage …

ABSTRACT Group A Streptococcus (GAS) is a human-adapted pathogen responsible for a
variety of diseases. The GAS M1UK lineage has contributed significantly to the recently …

Background The gradual replacement of the Streptococcus pyogenes M1global genotype by
a newly emergent M1UK variant is a global public health threat warranting increased …

Serotype M28 isolates of the bacterial pathogen the group A Streptococcus (GAS;
Streptococcus pyogenes), but not isolates of other serotypes, have a nonrandom association …

Introduction Rapid and accurate detection of group A Streptococcus (GAS) pharyngitis
allows for timely initiation of appropriate antibiotic treatment. This is important to prevent …