Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Mounting evidence supports the presence of biologically relevant G‐quadruplexes in single‐
cell organisms, but the existence of endogenous G‐quadruplex structures in mammalian …

G-quadruplexes are guanine-rich nucleic acids that fold by forming successive quartets of
guanines (the G-tetrads), stabilized by intra-quartet hydrogen bonds, inter-quartet stacking …

Abstract G-Quadruplexes (G4s) are widely studied secondary DNA/RNA structures, naturally
occurring when G-rich sequences are present. The strategic localization of G4s in genome …

The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT
promoter is disputed. One model features a structure with three stacked parallel G …

Quadruplex (G4) nucleic acids, a family of secondary structures formed by guanine-rich
sequences, exhibit an important structural polymorphism. We demonstrate here that G-rich …

Background G-rich sequences undergo unique structural equilibria to form G-quadruplexes
(G4) both in vitro and in cell systems. Several pathologies emerged to be directly related to …

Abstract G‐quadruplexes (G4), found in numerous places within the human genome, are
involved in essential processes of cell regulation. Chromosomal DNA G4s are involved for …

Human telomeres contain the repeat DNA sequence 5′-d (TTAGGG), with duplex regions
that are several kilobases long terminating in a 3′ single-stranded overhang. The structure …

In recent years, an increasing number of reports have been focused on the structure and
biological role of non-canonical nucleic acid secondary structures. Many of these studies …