Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …

Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-
associated genes, commonly occurs among aging human hematopoietic stem cells. We …

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

A novel, common, and potent cardiovascular risk factor has recently emerged: clonal
hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic mutations in …

Pathological and genomic profiling have transformed breast cancer care by matching
patients to targeted treatments. However, tumors evolve and evade therapeutic interventions …

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the expansion of
hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy …

As the use of next‐generation sequencing (NGS) for plasma cell‐free DNA (cfDNA)
continues to expand in clinical settings, accurate identification of circulating tumor DNA …

Historically, the link between chronic inflammation and cancer has long been speculated.
Only more recently, pre-clinical and epidemiologic data as well as clinical evidence all point …