Purpose Hyperacusis can be extremely debilitating, and at present, there is no cure. In this
detailed review of the field, we consolidate present knowledge in the hope of facilitating …

Perceptual abnormalities such as hyperacusis and tinnitus often occur after acoustic
overexposure. Although such exposure can also result in permanent threshold elevation …

Auditory brainstem-evoked response (ABR) thresholds were obtained in a longitudinal study
of C57BL/6J mice between 10 and 53 weeks old, with repeated testing every 2 weeks. On …

Tone detection and temporal gap detection thresholds were determined in CBA/CaJ mice
using a Go/No-go procedure and the psychophysical method of constant stimuli. In the first …

Noise-induced hearing loss generally induces loudness recruitment, but sometimes gives
rise to hyperacusis, a debilitating condition in which moderate intensity sounds are …

Excessive sound, vibration, and light are detrimental to rodent welfare, yet these parameters
are rarely recorded in vivaria. Whether housing environments exceed the suggested …

Proteins of the Homer1 immediate early gene family have been associated with
synaptogenesis and synaptic plasticity suggesting broad behavioral consequences of loss …

Using the acoustic startle reflex, prepulse inhibition (PPI) is typically demonstrated by the
interaction between two auditory stimuli presented in close temporal proximity. When a …

Over the years a number of drugs have been approved for human use with limited signs of
toxicity noted during preclinical risk assessment study designs but then show adverse …

The present study examined the developmental course of the age-related hearing loss and
its consequences on the expression of acoustic startle reflex (ASR) and prepulse inhibition …