Background The association between obesity and fracture risk may be skeletal site-and sex-
specific but results among studies are inconsistent. Whilst several studies reported higher …

Substantial evidence shows that skeletal fragility should be considered among the
complications associated with type 2 diabetes. Individuals with type 2 diabetes have …

Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin
D [25 (OH) D] in obese people are unknown. Low total 25 (OH) D may be due to low vitamin …

The purpose of this study is to determine whether low muscle mass (sarcopenia) or strength
(dynapenia), in the presence of obesity, are associated with increased risk for osteoporosis …

Objective, design and methods Roux-en-Y gastric bypass (RYGB) has proved successful in
attaining sustained weight loss but may lead to metabolic bone disease. To assess impact …

Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but
the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we …

High-resolution peripheral quantitative CT (HR-pQCT) is a low-dose three-dimensional
imaging technique, originally developed for in vivo assessment of bone microarchitecture at …

Background Obesity improves areal bone mineral density (aBMD). However, it is unknown
whether gender, ageing or the severity of obesity could modulate this effect and whether …

Background Trabecular bone score (TBS), which has been proposed to be used in
complementary with bone mineral density (BMD) to improve the assessment of fracture risk …

Background Most obese women with low-trauma fractures present normal areal bone
mineral density (aBMD), suggesting that other bone parameters are more determinant for …