The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …

From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

TDP1 and TDP2 were discovered and named based on the fact they process 3′-and 5′-
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

The maintenance of genetic stability is of crucial importance for any form of life. Prior to cell
division in each mammalian cell, the process of DNA replication must faithfully duplicate the …

To maintain genome stability, cells have evolved various DNA repair pathways to deal with
oxidative DNA damage. DNA damage response (DDR) pathways, including ATM-Chk2 and …

Background Triple-negative breast cancer (TNBC) is associated with aggressiveness and a
poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for …

In response to DNA double-strand breaks or oxidative stress, ATM-dependent DNA damage
response (DDR) is activated to maintain genome integrity. However, it remains elusive …

Exposures that methylate DNA potently induce DNA double-strand breaks (DSBs) and
chromosomal aberrations, which are thought to arise when damaged bases block DNA …

Base excision repair (BER) is an essential DNA repair pathway involved in the maintenance
of genome stability and thus in the prevention of human diseases, such as premature aging …