The correct development of blood vessels is crucial for all aspects of tissue growth and
physiology in vertebrates. The formation of an elaborate hierarchically branched network of …

Background—Diabetes mellitus impairs endothelial cell (EC) function and postischemic
reparative neovascularization by molecular mechanisms that are not fully understood …

Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of
protease genes in the human genome, are secreted serine proteases with diverse …

Angiogenesis or formation of new blood vessels from preexisting vasculature is a key
process in some physiological conditions such as wound healing, growth, and action of …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Background—Clinical trials in ischemic patients showed the safety and benefit of autologous
bone marrow progenitor cell transplantation. Non–bone marrow progenitor cells with …

Sustained and controllable local gene therapy is a potential method for treating osteoarthritis
(OA) through the delivery of therapeutic microRNAs (miRNAs) to targeted cells. However …

It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …

Background—The neurotrophin nerve growth factor (NGF) regulates neuron survival and
differentiation. Implication in neovascularization is supported by statement of NGF and its …

Therapeutic angiogenesis/vasculogenesis represents a new approach to treating patients
with ischemic disease not curable with conventional treatment. Manipulation of the …