Platelets are key vascular effectors in hemostasis, with activation signals leading to fast
recruitment, aggregation, and clot formation. The canonical process of hemostasis is well …

Bioassay technology has been proved important in the field of environmental monitoring,
disease diagnosis and clinical treatment. At present, diverse bioassay technologies have …

Programmed cell death protein 1 (PD-1) inhibitors are the most common immune-checkpoint
inhibitors and considered promising drugs for hepatocellular carcinoma (HCC). However, in …

The multifaceted functions of platelets in various physiological processes have long inspired
the development of therapeutic nanoparticles that mimic specific platelet features for disease …

ABSTRACT Introduction Von Willebrand disease (VWD) reflects the most common inherited
bleeding disorder, arising from defects or deficiencies in the von Willebrand factor (VWF) …

Innovation in therapies for patients with von Willebrand disease (VWD) has lagged far
behind that for hemophilia, creating inequity in the bleeding disorder community. Although …

ABSTRACT Introduction Von Willebrand disease (VWD) is the most common inherited
bleeding disorder, affecting about 0.6% to 1.3% of the population, and is characterized …

Manuscript background and aim The diagnosis and clinical care of patients with von
Willebrand disease (VWD) has continued to evolve since the characterization of the von …

Achieving rapid clotting and clot stability are important unmet goals of clinical management
of noncompressible hemorrhage. This study reports the development of a spatiotemporally …

Clinical trial programs for inherited bleeding disorders feature an array of innovative
prophylaxis options: engineered clotting factor concentrates, FVIIIa mimetics, gene …