The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

GG Graham, MJ Davies, RO Day, A Mohamudally… - …, 2013 - Springer
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors …

Pharmacogenetics, pharmacogenomics, and individualized medicine

Q Ma, AYH Lu, DR Sibley - Pharmacological reviews, 2011 - Elsevier
Individual variability in drug efficacy and drug safety is a major challenge in current clinical
practice, drug development, and drug regulation. For more than 5 decades, studies of …

Metabolomics enables precision medicine:“a white paper, community perspective”

RD Beger, W Dunn, MA Schmidt, SS Gross, JA Kirwan… - Metabolomics, 2016 - Springer
Abstract Introduction: Background to metabolomics Metabolomics is the comprehensive
study of the metabolome, the repertoire of biochemicals (or small molecules) present in …

PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses

LL Mazaleuskaya, K Sangkuhl, CF Thorn… - Pharmacogenetics …, 2015 - journals.lww.com
Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …

Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives

RJ Fontana - Gastroenterology, 2014 - Elsevier
Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of
drug dose, route, or duration of administration. Furthermore, idiosyncratic DILI is not a single …

Role of endoplasmic reticulum stress in drug‐induced toxicity

F Foufelle, B Fromenty - Pharmacology research & …, 2016 - Wiley Online Library
Drug‐induced toxicity is a key issue for public health because some side effects can be
severe and life‐threatening. These adverse effects can also be a major concern for the …

Challenges and opportunities of metabolomics

CH Johnson, FJ Gonzalez - Journal of cellular physiology, 2012 - Wiley Online Library
The metabolome is a data‐rich source of information concerning all the low‐molecular‐
weight metabolites in a biofluid, which can indicate early biological changes to the host due …

Central role of mitochondria in drug-induced liver injury

D Pessayre, B Fromenty, A Berson… - Drug metabolism …, 2012 - Taylor & Francis
A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …

Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine

X Wang, H Sun, A Zhang, W Sun, P Wang… - Journal of pharmaceutical …, 2011 - Elsevier
Traditional Chinese medicine (TCM) is a holistic approach to health that attempts to bring
the body, mind and spirit into harmony. Entering 21st century, TCM is getting more and more …

Xenobiotic metabolomics: major impact on the metabolome

CH Johnson, AD Patterson, JR Idle… - Annual review of …, 2012 - annualreviews.org
Xenobiotics are encountered by humans on a daily basis and include drugs, environmental
pollutants, cosmetics, and even components of the diet. These chemicals undergo …