Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …

Induction of heme oxygenase-1 (HO-1) is protective in tissue injury in models of allograft
rejection and vascular inflammation through either prevention of oxidative damage or via …

Heme oxygenase (HO) seems to be a novel protective factor with potent anti-inflammatory,
anti-oxidant, and anti-proliferative effects. HO-1, the inducible isoform, is expressed in …

The number of cases of type 2 diabetes (T2D) is increasing worldwide. This disease can be
characterized by insulin resistance and pancreatic β cell dysfunction, which lead to macro …

Embryonic stem (ES) cells have been proposed to be a powerful tool in the study of
pancreatic disease, as well as a potential source for cell replacement therapy in the …

Heme oxygenase (HO) has been shown to be important for attenuating the overall
production of reactive oxygen species (ROS) through its ability to degrade heme and to …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …