Understanding perturbations in synaptic function between health and disease states is
crucial to the treatment of neuropsychiatric illness. While genome-wide association studies …

Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …

Abstract Background The Toronto Adolescent and Youth (TAY) Cohort Study will
characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning …

Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …

Aberrant dopaminergic and glutamatergic function, particularly within the striatum and
hippocampus, has repeatedly been associated with the pathophysiology of schizophrenia …

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …

Considerable variations exist in the clinical presentation of psychiatric disorders. For any
given diagnostic construct, there are several thousand combinations of symptoms that can …

Background The synaptic hypothesis is an influential theory of the pathoetiology of
schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the …

Complex brain disorders like schizophrenia may have multifactorial origins related to mis-
timed heritable and environmental factors interacting during neurodevelopment. Infections …

In this issue of Molecular Psychiatry, we have multiple articles that present exciting
advances in psychosis and autism spectrum disorder (ASD). We start with interesting …