Potential therapeutic role of pituitary adenylate cyclase-activating polypeptide for dry eye disease

T Hirabayashi, J Shibato, A Kimura… - International Journal of …, 2022 - mdpi.com
Dry eye disease (DED) is caused by a reduction in the volume or quality of tears. The
prevalence of DED is estimated to be 100 million in the developed world. As aging is a risk …

Extreme thermal noxious stimuli induce pain responses in zebrafish larvae

V Malafoglia, M Colasanti, W Raffaeli… - Journal of cellular …, 2014 - Wiley Online Library
Exposing tissues to extreme high or low temperature leads to burns. Burned animals sustain
several types of damage, from the disruption of the tissue to degeneration of axons …

Viral and bacterial septicaemic infections modulate the expression of PACAP splicing variants and VIP/PACAP receptors in brown trout immune organs

B Gorgoglione, Y Carpio, CJ Secombes… - Fish & shellfish …, 2015 - Elsevier
Abstract Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and PACAP-Related
Peptide (PRP) are structurally similar peptides encoded in the same transcripts. Their …

Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina

M Lakk, B Szabó, B Völgyi, R Gábriel… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: The ubiquitous pituitary adenylate cyclase-activating peptide (PACAP) has a
disparate array of functions in development (eg, proliferation and apoptosis). Among three …

GHRH, PRP-PACAP and GHRHR target sequencing via an ion torrent personal genome machine reveals an association with growth in orange-spotted grouper …

L Guo, J Xia, S Yang, M Li, X You, Z Meng… - International Journal of …, 2015 - mdpi.com
Growth hormone-releasing hormone (GHRH) and the receptor, GHRHR, constitute important
components of the hypothalamus-pituitary growth axis and act on the downstream growth …

Association of pituitary adenylate cyclase-activating polypeptide and myogenic factor 6 genes with growth traits in Nile tilapia (Oreochromis niloticus)

G Zou, Y Zhu, H Liang, Z Li - Aquaculture international, 2015 - Springer
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic hormone that
enhances and stimulates the secretion of growth hormone; while myogenic factor 6 (MYF6) …

Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome

B Eneman, MA Elmonem, LP Van Den Heuvel… - PLoS …, 2017 - journals.plos.org
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an inhibitor of
megakaryopoiesis and platelet function. Recently, PACAP deficiency was observed in …

Cloning and differential expression pattern of pituitary adenylyl cyclase-activating polypeptide and the PACAP-specific receptor in darkbarbel catfish Pelteobagrus …

M Xu, L Long, L Chen, J Qin, L Zhang, N Yu… - … and Physiology Part B …, 2012 - Elsevier
Pituitary adenylyl cyclase-activating polypeptide (PACAP) can mediate growth hormone and
gonadotropin release in teleost pituitary via PACAP receptors. In this study, the full-length …

[HTML][HTML] Pituitary adenylate cyclase activating polypeptide (PACAP1–38) exerts both pro and anti-apoptotic effects on postnatal retinal development in rat

Z Nyisztor, V Denes, A Kovacs-Valasek, O Hideg… - Neuroscience, 2018 - Elsevier
Abstract PACAP1–38, a ubiquitous and multifunctional regulator has been in the focus of
neurotoxicity research due to its impressive neuroprotective potential. Although the literature …

Démonstration du rôle particulier du segment C-Terminal 28-38 du pituitary adenylate cyclase-activacting polypeptide (PACAP) et caractérisation de modulateurs …

M Poujol de Molliens - 2019 - espace.inrs.ca
En accroissement du nombre de maladies neurodégénératives est observé depuis
plusieurs années. On estime aujourd'hui que 55 000 Canadiens ont reçu un diagnostic de la …