Nanomaterial-based microfluidic systems for cancer biomarker detection: recent applications and future perspectives

Y Xiang, C Hu, G Wu, S Xu, Y Li - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Detecting cancer biomarkers (eg, circulating tumor cells, extracellular vehicles, nucleic
acids, and protein biomarkers) is vital for risk assessment and early diagnosis. Nanomaterial …

Development of Nucleic‐Acid‐Based Electrochemical Biosensors for Clinical Applications

Z Zhang, P Sen, BR Adhikari, Y Li… - Angewandte …, 2022 - Wiley Online Library
Nucleic acids are remarkable molecules. In addition to Watson–Crick base pairing, the
different structural motifs of these molecules can bind non‐nucleic acid targets or catalyze …

Paper‐based wearable electrochemical sensors: a new generation of analytical devices

PB Deroco, D Wachholz Junior, LT Kubota - Electroanalysis, 2023 - Wiley Online Library
Over the past few years, the emergence of electrochemical wearable sensors has attracted
considerable attention because of their promising application in point‐of‐care testing due to …

Programmable DNA-fueled electrochemical analysis of lung cancer exosomes

L Sha, B Bo, F Yang, J Li, Y Cao, J Zhao - Analytical Chemistry, 2022 - ACS Publications
Molecular diagnostics devoted to discover and monitor new biomarkers is gaining
increasing attention in clinical diagnosis. In this work, a programmable DNA-fueled …

COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson's Disease Model Mouse Brain

L Zhou, R Yang, X Li, N Dong, B Zhu… - Journal of the …, 2023 - ACS Publications
Parkinson's disease (PD) is a progressive neurodegenerative disorder causing the loss of
dopaminergic neurons in the substantia nigra and the drastic depletion of dopamine (DA) in …

Rapid quantitation of SARS-CoV-2 antibodies in clinical samples with an electrochemical sensor

SS Timilsina, N Durr, P Jolly, DE Ingber - Biosensors and Bioelectronics, 2023 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic is caused by several variants
of severe acute respiratory syndrome coronavirus-2 virus (SARS-CoV-2). With the roll-out of …

Hydrogel-coated microelectrode resists protein passivation of in vivo amperometric sensors

Y Yin, H Zeng, S Zhang, N Gao, R Liu… - Analytical …, 2023 - ACS Publications
Passivation of electrodes caused by nonspecific adsorption of protein can dramatically
reduce sensing sensitivity and accuracy, which is a great challenge for in vivo …

Simultaneous detection of C-reactive protein and lipopolysaccharide based on a dual-channel electrochemical biosensor for rapid Gram-typing of bacterial sepsis

TC Lu, YJ Yang, Y Zhong, QZ Qiu, ZH Chen… - Biosensors and …, 2024 - Elsevier
Sepsis is a life-threatening multi-organ failure syndrome, with bacterial infections being the
most common cause. Rapid Gram-typing is imperative to assist in antibiotic intervention. C …

Affinity-based electrochemical sensors for biomolecular detection in whole blood

EC Wilkirson, KL Singampalli, J Li, DD Dixit… - Analytical and …, 2023 - Springer
The detection and/or quantification of biomarkers in blood is important for the early
detection, diagnosis, and treatment of a variety of diseases and medical conditions. Among …

Multiplexed electrochemical assays for clinical applications

M Sharafeldin, JF Rusling - Current opinion in electrochemistry, 2023 - Elsevier
Rapid, accurate diagnoses are central to future efficient healthcare to identify diseases at
early stages, avoid unnecessary treatment, and improve outcomes. Electrochemical …