The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a
potential adjunctive therapy to antibiotics, infectious source control, and supportive care for …

Despite the targeting of traditional risk factors for cardiovascular disease, disease burden
has not been completely eliminated. Thiamine is an essential cofactor in carbohydrate …

Background Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it
remains unclear whether thiamine status is lower in individuals with diabetes compared to …

Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-
line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug …

Thiamine acts as a coenzyme for transketolase (Tk) and for the pyruvate dehydrogenase
and α-ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for …

Growing prevalence of diabetes (type 2 as well as type 1) and its related morbidity due to
vascular complications creates a large burden on medical care worldwide. Understanding …

Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Although
hyperglycaemia has been determined as the most important risk factor, hypoxia also plays a …

Objective Diabetes has been found to be associated with low levels of thiamine stores in the
body, as thiamine directly affects carbohydrate metabolism. Amplified renal clearance of …

Zearalenone (ZEA), a Fusarium mycotoxin that contaminates cereal crops worldwide, has
been shown to affect the male reproductive system and trigger reactive oxygen species …

Urine has the potential to become a better source of biomarkers. Urinary proteins are
affected by many factors; therefore, differentiating between the variables associated with any …