The high prevalence of rotator cuff tears poses challenges to individual patients and the
healthcare system at large. This orthopedic injury is complicated further by high rates of …

Despite the ravages of long term denervation there is structural and ultrastructural evidence
for survival of muscle fibers in mammals, with some fibers surviving at least ten months in …

Skeletal muscle maintenance depends on motor innervation at neuromuscular junctions
(NMJs). Multiple mechanisms contribute to NMJ repair and maintenance; however muscle …

Spinal and bulbar muscular atrophy (SBMA) is an adult form of X-linked motor neuron
disease caused by an expansion of a CAG repeat sequence in the first exon of the androgen …

During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle
volume and function impacting mobility and quality of life. Muscle loss is often associated …

The ability of very old animals to make new muscle after injury remains controversial. This
issue has major implications for the regenerative potential of damaged geriatric human …

Neurogenic atrophy refers to the loss of muscle mass and function that results directly from
injury or disease of the peripheral nervous system. Individuals with neurogenic atrophy may …

Satellite cells are companions to voluntary muscle fibres, and are named for their intimate
positional orsatellite'relationship, as if revolving around fibres, like a satellite moon around …

Tissue development and regeneration share common features, since modules of regulatory
pathways and transcription factors that are crucial for prenatal development are redeployed …

While changes in muscle protein synthesis and degradation have long been known to
contribute to muscle wasting, a body of literature has arisen which suggests that regulation …