Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

The neural circuitry that mediates mood under normal and abnormal conditions remains
incompletely understood. Most attention in the field has focused on hippocampal and frontal …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

Circadian oscillations in mammalian physiology and behavior are regulated by an
endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known …

Circadian rhythms are∼ 24-h oscillations in behavior and physiology, which are internally
generated and function to anticipate the environmental changes associated with the solar …

Sleep disturbance is increasingly recognized as an important, but understudied, mechanism
in the complex and multi-factorial causation of the symptoms and functional disability …

All available antidepressant medications are based on serendipitous discoveries of the
clinical efficacy of two classes of antidepressants more than 50 years ago. These tricyclic …

Mice deficient in the circadian transcription factor BMAL1 (brain and muscle ARNT-like
protein) have impaired circadian behavior and demonstrate loss of rhythmicity in the …

Heterochromatin has been defined as deeply staining chromosomal material that remains
condensed in interphase, whereas euchromatin undergoes de-condensation …

Mice carrying a null mutation in the Period 1 (mPer1) gene were generated using embryonic
stem cell technology. Homozygous mPer1 mutants display a shorter circadian period with …