Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

Summary The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was
published in 2017, which comprehensively reviewed and provided recommendations on …

Background A recurrent tuberculosis (TB) episode results from exogenous reinfection or
relapse after cure. The use of genotyping allows the distinction between both. Methods We …

• Most patients with TB disease should be initiated on a regimen of isoniazid, rifampin,
pyrazinamide and ethambutol until results of genotypic or phenotypic drug susceptibility are …

Background Despite data suggesting elevated morbidity and mortality among people who
have survived tuberculosis disease, the impact of respiratory tuberculosis on healthcare …

Background: Measurements TB incidence and mortality are crucial for monitoring progress
towards SDG goals for TB. Until recently, WHO estimated TB burden in India with applied …

Rationale: Standardized dosing of antitubercular drugs contributes to a substantial
incidence of toxicities, inadequate treatment response, and relapse, in part due to variable …

Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes
in drug-susceptible disease, suggesting that treatment success depends on features that are …

Background Pulmonary tuberculosis (PTB) is frequently associated with chronic respiratory
impairment despite microbiological cure. There are only a few clinical research studies that …

Objectives To determine tuberculosis (TB) recurrence in previously successfully treated
patients in a routine program setting and baseline characteristics associated with TB …