Highlights•Single-cell sequencing reveals enormous macrophage complexity.•Strong
functional imprinting of tumor-associated macrophages by tumor microenvironment.• …

The tumor necrosis factor superfamily (TNFSF) and their receptors (TNFRSF) are important
regulators of the immune system, mediating proliferation, survival, differentiation, and …

Immunotherapies modulate the function of immune cells to eradicate cancer cells through
various mechanisms. These therapies are successful across a spectrum of cancers, but they …

Immunostimulatory antibody conjugates (ISACs) as a promising new generation of targeted
therapeutic antibody-drug conjugates (ADCs), that not only activate innate immunity but also …

Simple Summary Targeting of CD40 with antibodies attracts significant translational interest.
While inhibitory CD40 targeting appears particularly attractive in the field of organ …

Advancing novel immunotherapy strategies requires refined tools in preclinical research to
thoroughly assess drug targets, biodistribution, safety, and efficacy. Light sheet fluorescence …

Arming oncolytic viruses with transgenes encoding immunomodulators improves their
therapeutic efficacy by enhancing and/or sustaining the innate and adaptive anti-tumoral …

Background The approval of immune checkpoint blockade (ICB) targeting CTLA-4, PD-1,
and PD-L1 marked a significant breakthrough in cancer therapy, demonstrating remarkable …

Cancer is a complex disease that thrives by creating an environment in the body that fosters
its growth and evasion of immune detection. This" tumor microenvironment"(TME) is made …

Many new immunotherapeutic approaches aim on the stimulatory targeting of receptors of
the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) using antibodies with …