Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …

Introduction: Heparin-induced thrombocytopenia (HIT) is known for its strong association
with thrombosis and distinct pathogenesis involving anti-PF4/polyanion antibodies that …

Platelet integrin αIIbβ3 is maintained in a bent inactive state (low affinity to physiologic
ligand), but can rapidly switch to a ligand-competent (high-affinity) state in response to …

Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that
is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

Consensus guidelines for periprocedural management of coagulation status and hemostasis
risk in percutaneous image-guided interventions Consensus guidelines for periprocedural …

Abstract Platelet transfusions total> 2.17 million apheresis-equivalent units per year in the
United States and are derived entirely from human donors, despite clinically significant …

Although drugs are a common cause of acute immune-mediated thrombocytopenia in
adults, the drug etiology is often initially unrecognized. Most cases of drug-induced …

Drug-induced immune thrombocytopenia (DITP) is a challenging clinical problem that is
under-recognized, difficult to diagnose and associated with severe bleeding complications …

A low platelet count is a frequently encountered haematological abnormality in patients
treated in intensive treatment units (ITU s). Although severe thrombocytopenia (platelet …