[PDF][PDF] Altered platelet function in cirrhosis of the liver: impairment of inositol lipid and arachidonic acid metabolism in response to agonists

G Laffi, F Cominelli, M Ruggiero, S Fedi… - …, 1988 - Wiley Online Library
Hemorrhagic disorders are common in patients with liver cirrhosis and result from several
factors including impaired platelet function. We evaluated platelet aggregation and …

Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment.

JA Osborne, PH Lento, MR Siegfried… - The Journal of …, 1989 - Am Soc Clin Investig
Hypercholesterolemia was induced in New Zealand white rabbits by feeding them a 0.5%
cholesterol-enriched rabbit chow for 2 wk. Half of the cholesterol-fed rabbits were given …

Platelets and the lipoproteins: native, modified and platelet modified lipoproteins

E Malle, W Sattler - Platelets, 1994 - Taylor & Francis
Under physiological conditions human blood platelets play a beneficial role in fibrinolysis
and regulate the balance with prostacyclin and other factors derived from the endothelium …

Platelet deposition at high shear rates is enhanced by high plasma cholesterol levels. In vivo study in the rabbit model.

JJ Badimon, L Badimon, VT Turitto… - … and Thrombosis: A …, 1991 - Am Heart Assoc
We have studied the effects of high plasma cholesterol levels on platelet-vessel wall
interactions under high shear rate conditions typical of the apex of stenotic arteries (2,600 …

Lovastatin decreases plasma and platelet cholesterol levels and normalizes elevated platelet fluidity and aggregation in hypercholesterolemic patients

E Hochgraf, Y Levy, M Aviram, JG Brook, U Cogan - Metabolism, 1994 - Elsevier
The lipid composition of whole platelets and the fluidity of platelet membranes, as well as the
sensitivity of the cell to aggregation, were studied in type IIA hypercholesterolemic human …

Molecular mechanism underlying impaired platelet responsiveness in liver cirrhosis

G Laffi, F Cominelli, M Ruggiero, S Fedi… - FEBS …, 1987 - Wiley Online Library
We have studied platelet function in 10 patients with severe liver cirrhosis, compared to
healthy subjects. Using washed platelets, we have investigated the molecular mechanism …

Membrane Fluidity, Membrane Lipid Pattern, and Cytosolic Ca2+ Content in Platelets from a Group of Type II Diabetic Patients with Macrovascular Complications

G Caimi, RL Presti, M Montana, B Canino… - Diabetes …, 1995 - Am Diabetes Assoc
OBJECTIVE To evaluate platelet membrane fluidity and some platelet metabolic parameters
in type II diabetic patients with macrovascular complications. RESEARCH DESIGN AND …

Platelet membrane fluidity in type IIA, type IIB and type IV hyperlipoproteinemia

E Malle, W Sattler, E Prenner, HJ Leis, I Karàdi… - Atherosclerosis, 1991 - Elsevier
Fluorescence spectroscopy, a very sensitive index for measuring the biophysical properties
of living cell systems, was used to examine the structural order of intact, resting, gel-filtered …

Increase in Membrane Cholesterol Content Enhances Phospholipase A2 Activity and Endoperoxide Receptor Response in Human Platelets

T Sato, T Fujii, T Hashizume, T Fujii - Platelets, 1990 - Taylor & Francis
The effect of cholesterol-enrichment in platelet membranes on U46619 binding to the
specific receptor and phospholipase A2 and C activities was studied using cholesterol …

Whole blood aggregation and plasma lyso‐PAF related to smoking and atherosclerosis

MJ Sturm, JM Strophair, PJ Kendrew… - Clinical and …, 1989 - Wiley Online Library
Aggregation of diluted whole blood (impedance method) and thromboxane B2 production
during aggregation were measured in cigarette smokers and non‐smokers, aged 41–68 …