The keratins are the typical intermediate filament proteins of epithelia, showing an
outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing …

Canine mammary tumors (CMTs) are the most common neoplasm in intact female dogs.
Canine mammary cancer (CMC) represents 50% of CMTs, and besides surgery, which is the …

Cancer cells within individual tumors often exist in distinct phenotypic states that differ in
functional attributes. While cancer cell populations typically display distinctive equilibria in …

Although the existence of mammary stem cells has been suggested by serial transplantation
studies in mice, their identification has been hindered by the lack of specific surface markers …

Cells with distinct phenotypes including stem-cell-like properties have been proposed to
exist in normal human mammary epithelium and breast carcinomas, but their detailed …

Here we describe the comprehensive gene expression profiles of each cell type composing
normal breast tissue and in situ and invasive breast carcinomas using serial analysis of …

Breast cancer is not a single disease, but rather is composed of distinct subtypes associated
with different clinical outcomes. Understanding this heterogeneity is key for the development …

The discovery of the first gene associated with hereditary breast cancer, BRCA1, was
anticipated to greatly increase our understanding of both hereditary and sporadic forms of …

A basal epithelial phenotype is found in not more than 15% of all invasive breast cancers.
Microarray studies have shown that this phenotype is associated with breast cancers that …

We have examined basal and luminal cell cytokeratin expression in 1944 cases of invasive
breast carcinoma, using tissue microarray (TMA) technology, to determine the frequency of …