Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on
the brain and behavior. One-dose ethanol exposure induces transient plastic changes in …

GABAA receptors form the major class of inhibitory neurotransmitter receptors in the
mammalian brain. This review sets out to summarize the evidence that variations in genes …

Alcohol use disorder (AUD) is a chronic relapsing condition characterized by compulsive
alcohol-seeking behaviors, with serious detrimental health consequences. Despite high …

A current survey and synthesis of the most important findings in our understanding of the
neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series …

The role of oxytocin in attenuating the abuse of licit and illicit drugs, including the
psychostimulant methamphetamine, has been examined with increased ferocity in recent …

Long-lasting changes in synaptic function (ie, synaptic plasticity) have long been thought to
contribute to information storage in the nervous system. Although synaptic plasticity mainly …

Delayed maturation of the adolescent prefrontal cortex may render it particularly vulnerable
to insults, including those associated with drugs of abuse. Using a rat model of binge alcohol …

Several previous studies showed that hippocampus and cortex are affected in Alzheimer's
disease (AD). However, other brain regions have also been found to be affected and could …

Drug use poses a serious threat to health systems throughout the world. The number of
consumers rises every year being alcohol the drug of abuse most consumed causing 3 …