Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many
chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate …

Osteogenesis Imperfecta (OI) comprises a heterogeneous group of patients who share bone
fragility and deformities as the main characteristics, albeit with different degrees of severity …

TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …

Surfeit 4 is a polytopic transmembrane protein that primarily resides in the endoplasmic
reticulum (ER) membrane. It is ubiquitously expressed and functions as a cargo receptor …

Lipid droplets (LDs), which are active organelles, derive from the monolayer membrane of
the endoplasmic reticulum and encapsulate neutral lipids internally. LD-associated proteins …