Mitochondrial dysfunction in lung ageing and disease

SM Cloonan, K Kim, P Esteves, T Trian… - European Respiratory …, 2020 - Eur Respiratory Soc
Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence
of numerous new avenues of exciting mitochondria-related research including …

Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

The distribution and role of the CFTR protein in the intracellular compartments

A Lukasiak, M Zajac - Membranes, 2021 - mdpi.com
Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is
caused by mutations in the gene encoding CFTR with the most common phenylalanine …

Microcystin-LR-induced changes of hepatopancreatic transcriptome, intestinal microbiota, and histopathology of freshwater crayfish (Procambarus clarkii)

Y Zhang, Z Li, S Kholodkevich, A Sharov, Y Feng… - Science of the Total …, 2020 - Elsevier
As a hepatotoxin, microcystin-LR (MC-LR) poses a great threat to aquatic organisms. In this
research, the hepatopancreatic transcriptome, intestinal microbiota, and histopathology of …

Knock-in strategy for editing human and zebrafish mitochondrial DNA using mito-CRISPR/Cas9 system

WP Bian, YL Chen, JJ Luo, C Wang, SL Xie… - ACS Synthetic …, 2019 - ACS Publications
The mitochondria DNA (mtDNA) editing tool, zinc finger nucleases (ZFNs), transcription
activator-like effector nuclease (TALENs), and clustered regularly interspaced short …

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

T Madácsy, P Pallagi, J Maleth - Frontiers in Physiology, 2018 - frontiersin.org
Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in
secretory epithelial cells due to the defective ion flux across the cystic fibrosis …

[HTML][HTML] CFTR activity and mitochondrial function

AG Valdivieso, TA Santa-Coloma - Redox biology, 2013 - Elsevier
Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease, caused by
mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator …

The chloride anion as a signalling effector

ÁG Valdivieso, TA Santa‐Coloma - Biological Reviews, 2019 - Wiley Online Library
The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

A systematic review of the impact of mitochondrial variations on male infertility

H Amor, ME Hammadeh - Genes, 2022 - mdpi.com
According to current estimates, infertility affects one in four couples trying to conceive.
Primary or secondary infertility can be due either to both partners or only to the man or the …

Role of cystic fibrosis bronchial epithelium in neutrophil chemotaxis

G Cabrini, A Rimessi, M Borgatti, I Lampronti… - Frontiers in …, 2020 - frontiersin.org
A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil
infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The …