Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Conventional light-driven cancer therapeutics require oxygen and visible light to indirectly
damage biomolecules, limiting their efficacy in deep, hypoxic tumours. Here we report the …

Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor
development from initiation to metastasis. EMT could be regarded as a continuum, with …

The immune-suppressive tumour microenvironment represents a major obstacle to effective
immunotherapy,. Pathologically activated neutrophils, also known as polymorphonuclear …

Localized radiotherapy (RT) induces an immunogenic antitumor response that is in part
counterbalanced by activation of immune evasive and tissue remodeling processes, eg, via …