A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …

G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …

G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …

That primaquine and other drugs can trigger acute haemolytic anaemia in subjects who
have an inherited mutation of the glucose 6‐phosphate dehydrogenase (G6 PD) gene has …

Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency.
Understanding the relationship between G6PD genotype and the phenotypic expression of …

Drug discovery and development is an expensive, time-consuming, and risky enterprise. In
order to accelerate the drug development process with reduced risk of failure and relatively …

Drug-induced acute hemolytic anemia led to the discovery of G6PD deficiency. However,
most clinical data are from isolated case reports. In 2 clinical trials of antimalarial …

Restrictions on the cultivation and ingestion of fava beans were first reported as early as the
fifth century BC. Not until the late 19th century were clinical descriptions of fava-induced …

Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is common in
populations living in malaria endemic areas. G6PD genotype and phenotype were …

The scientific community worldwide has realized that malaria elimination will not be possible
without development of safe and effective transmission-blocking interventions. Primaquine …