Prognostic biomarkers in uveal melanoma: The status quo, recent advances and future directions

NJ Lamas, A Martel, S Nahon-Estève, S Goffinet… - Cancers, 2021 - mdpi.com
Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Stability, delivery and functions of human sperm RNAs at fertilization

E Sendler, GD Johnson, S Mao… - Nucleic acids …, 2013 - academic.oup.com
Increasing attention has focused on the significance of RNA in sperm, in light of its
contribution to the birth and long-term health of a child, role in sperm function and diagnostic …

Proteomic identification of human sperm proteins

J Martínez‐Heredia, JM Estanyol, JL Ballescà… - …, 2006 - Wiley Online Library
Conventional 1‐DE has in the past provided a wealth of information concerning the major
sperm proteins. However, so far there are relatively few reports exploiting the potential of the …

Proteomic characterization of the human sperm nucleus

S de Mateo, J Castillo, JM Estanyol, JL Ballescà… - …, 2011 - Wiley Online Library
Generating a catalogue of sperm nuclear proteins is an important first step towards the
clarification of the function of the paternal chromatin transmitted to the oocyte upon …

Biotechnological approaches to the treatment of aspermatogenic men

PM Aponte, S Schlatt, LR Franca - Clinics, 2013 - SciELO Brasil
Aspermatogenesis is a severe impairment of spermatogenesis in which germ cells are
completely lacking or present in an immature form, which results in sterility in approximately …

Copy number variations in testicular maturation arrest

A Halder, P Kumar, M Jain, VK Iyer - Andrology, 2017 - Wiley Online Library
Testicular maturation arrest is characterized by interruption of germ cell development and
differentiation. Genetic factors play important role in the causation of human disease …

[HTML][HTML] SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma

YJ Hsiao, KY Su, YC Hsu, GC Chang, JS Chen… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract SPANXA (Sperm Protein Associated with the Nucleus on the X-chromosome, family
members A1/A2) acts as a cancer-testis antigen expressed in normal testes, but …

Evaluation of potential protein biomarkers in patients with high sperm DNA damage

B Behrouzi, S Kenigsberg, N Alladin… - Systems biology in …, 2013 - Taylor & Francis
The laboratory evaluation of male infertility remains an essential area of research as 40-60%
of infertility cases are attributable to male-related factors. Current sperm analysis methods …

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27

N Kouprina, A Pavlicek, VN Noskov… - Genome …, 2005 - genome.cshlp.org
Genetic linkage studies indicate that germline variations in a gene or genes on chromosome
Xq27–28 are implicated in prostate carcinogenesis. The linkage peak of prostate cancer …

SPANX-A/D protein subfamily plays a key role in nuclear organisation, metabolism and flagellar motility of human spermatozoa

I Urizar-Arenaza, N Osinalde, V Akimov, M Puglia… - Scientific reports, 2020 - nature.com
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes
encode a protein family (SPANX-A,-B,-C and-D), whose expression is limited to the testis …