Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

The inheritance of parental histones across the replication fork is thought to mediate
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …

Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) make up the largest family of
transcription factors in humans. These proteins emerged in the last common ancestor of …

Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …

The involvement of RNA interference (RNAi) in heterochromatin formation has become clear
largely through studies in the fission yeast Schizosaccharomyces pombe and plants like …

HP1 proteins are central to the assembly and spread of heterochromatin containing histone
H3K9 methylation. The chromodomain (CD) of HP1 proteins specifically recognizes the …

Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across
large domains and can be epigenetically inherited in a self-propagating manner …

Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is
nucleated at specific genomic sites but can self-propagate across extended domains and …