Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

Importance Migraine is a disabling neurological disease characterized by severe headache
attacks. Treatment options reduce migraine frequency for many patients, but adverse effects …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however,
many patients with migraine do not benefit from drugs that antagonize the CGRPergic …

Importance Galcanezumab (LY2951742), a monoclonal antibody against calcitonin gene-
related peptide (CGRP), is one of a novel class of new medicines for migraine prevention …

The most important primary headaches (ie independent disorders that are not caused by
another disease) are migraine, tension-type headache and cluster headache. All primary …

Background Recent studies on migraineurs and our own animal experiments have revealed
that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has an important role …

Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …

Migraine is a common condition with disabling attacks that burdens people in the prime of
their working lives. Despite years of research into migraine pathophysiology and …