Compositions and methods for analyte detection

D Levner, JH Lee, GM Church, M Super - US Patent 10,227,639, 2019 - Google Patents
The inventions provided herein relate to detection reagents, compositions, methods, and kits
comprising the detection reagents for use in detection, identification, and/or quanti fication of …

Method for generating a three-dimensional nucleic acid containing matrix

GM Church, JH Lee, RC Terry… - US Patent 10,494,662, 2019 - Google Patents
US10494662B2 - Method for generating a three-dimensional nucleic acid containing matrix -
Google Patents US10494662B2 - Method for generating a three-dimensional nucleic acid …

Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing

GM Church, ER Daugharthy, RC Terry - US Patent 11,447,807, 2022 - Google Patents
5,830,708 A 5,834,758 A 5,871,921 A 6,068,979 A 6,083,726 A 6,194,148 B1 6,306,597 B1
6,534,266 B1 6,586,176 B1 6,632,655 B1 7,255,994 B2 7,323,305 B2 7,427,479 B2 …

Methods and systems for sample processing or analysis

E Daugharthy, R Terry - US Patent 11,193,163, 2021 - Google Patents
8,460,865 B2 6/2013 Chee et al. 8,501,459 B2 8/2013 Chen et al. 8,551,710 B2 10/2013
Bernitz et al. 9,201,063 B2 12/2015 Sood et al. 9,217,151 B2 12/2015 Yin et al. 9,914,967 …

Sequencing by structure assembly

GM Church, RC Terry, F Vigneault… - US Patent …, 2019 - Google Patents
US10501791B2 - Sequencing by structure assembly - Google Patents US10501791B2 -
Sequencing by structure assembly - Google Patents Sequencing by structure assembly …

Method for generating a three-dimensional nucleic acid containing matrix

GM Church, JH Lee, RC Terry… - US Patent 10,138,509, 2018 - Google Patents
US10138509B2 - Method for generating a three-dimensional nucleic acid containing matrix
- Google Patents US10138509B2 - Method for generating a three-dimensional nucleic acid …

Iterative expansion microscopy

ES Boyden, JB Chang, F Chen, PW Tillberg - US Patent 11,408,890, 2022 - Google Patents
The present invention leverages the techniques for expansion microscopy (ExM) to provide
improved high-throughput super-resolution whole-organ imaging methodology to image …

Spatial sequencing of nucleic acids using DNA origami probes

GM Church, RC Terry, F Vigneault - US Patent 10,640,826, 2020 - Google Patents
US10640826B2 - Spatial sequencing of nucleic acids using DNA origami probes - Google
Patents US10640826B2 - Spatial sequencing of nucleic acids using DNA origami probes …

Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix

ER Daugharthy, RC Terry, JH Lee, GM Church… - US Patent …, 2019 - Google Patents
US10266888B2 - Method and apparatus for volumetric imaging of a three-dimensional nucleic
acid containing matrix - Google Patents US10266888B2 - Method and apparatus for volumetric …

Methods for high-throughput labelling and detection of biological features in situ using microscopy

GM Church, JH Lee, ER Daugharthy - US Patent 10,179,932, 2019 - Google Patents
US10179932B2 - Methods for high-throughput labelling and detection of biological features in
situ using microscopy - Google Patents US10179932B2 - Methods for high-throughput labelling …