Over half of human genomic DNA is composed of repetitive sequences generated
throughout evolution by prolific mobile genetic parasites called transposable elements …

Livestock and poultry play a significant role in human nutrition by converting agricultural by-
products into high-quality proteins. To meet the growing demand for safe animal protein …

Summary Long interspersed element 1 (L1) retrotransposons are implicated in human
disease and evolution. Their global activity is repressed by DNA methylation, but …

Repressive KRAB domain-containing zinc-finger proteins (KRAB-ZFPs) are abundant in
mammalian genomes and contribute both to the silencing of transposable elements (TEs) …

Background Endogenous expression of L1 mRNA is the first step in an L1-initiated
mutagenesis event. However, the contribution of individual cell types to patterns of organ …

Transposable elements (TEs) are recognized for their great impact on the functioning and
evolution of their host genomes. They are associated to various deleterious effects, which …

Genetic variants, including mobile element insertions (MEIs), are known to impact the
epigenome. We hypothesized that genome graphs, which encapsulate genetic diversity …

LINE-1 retrotransposons are sequences capable of copying themselves to new genomic loci
via an RNA intermediate. New studies implicate LINE-1 in a range of diseases, especially in …

L1 elements can cause DNA damage and genomic variation via retrotransposition and the
generation of endonuclease-dependent DNA breaks. These processes require L1 ORF2p …

SUMMARY Long interspersed element-1 (L1) retrotransposons play important roles in
human disease and evolution. Their global activity is repressed by DNA methylation, but …