Abstract Treatment resistant schizophrenia (TRS) refers to the significant proportion of
schizophrenia patients who continue to have symptoms and poor outcomes despite …

Although treatment-resistant schizophrenia (TRS) was described 50 years ago 1 and has a
gold standard treatment with clozapine based on well-defined criteria, 2 there is still a matter …

Objective Meta-analyses have demonstrated the efficacy of various interventions for
psychosis, and a small number of studies have compared such interventions. The aim of this …

Objective Support for cognitive-behavioral therapy (CBT) for psychosis has accumulated,
with several reviews and meta-analyses indicating its effectiveness for various intended …

Background: Although clozapine is the most effective medication for treatment refractory
schizophrenia, only 40% of people will meet response criteria. We therefore undertook a …

Abstract About 40%-70% of the patients with treatment-resistant schizophrenia have a poor
response to adequate treatment with clozapine. The impact of clozapine-resistant …

Background: Treatment options for clozapine resistance are diverse whereas, in contrast,
the evidence for augmentation or combination strategies is sparse. Aims: We aimed to …

There is no established treatment for patients with clozapine-resistant schizophrenia (CRS).
Clozapine augmentation strategies with antipsychotics or others substances are effective in …

Objective To integrate all evidence derived from randomized controlled trials (RCTs) of both
pharmacological and nonpharmacological augmentation interventions for clozapine …

Objective The aim of this systematic review and meta-analysis was to characterize ultra-
treatment-resistant Schizophrenia also known as clozapine-resistant schizophrenia (CRS) …