Drug hypersensitivity in HIV infection

J Peter, P Choshi, RJ Lehloenya - Current opinion in allergy and …, 2019 - journals.lww.com
IM-ADRs remain a challenge in persons living with HIV. The complexities posed by
polypharmacy, overlapping drug toxicities, drug interactions, overlap of IM-ADRs with other …

Key toxicity issues with the WHO-recommended first-line antiretroviral therapy regimen

JP Mouton, K Cohen, G Maartens - Expert review of clinical …, 2016 - Taylor & Francis
Introduction: WHO recommends tenofovir, efavirenz, and lamivudine or emtricitabine for first-
line antiretroviral therapy (ART) in adults, which replaced more toxic regimens using …

[HTML][HTML] African Pharmacogenomics Consortium: consolidating pharmacogenomics knowledge, capacity development and translation in Africa: consolidating …

C Dandara, C Masimirembwa, YZ Haffani… - AAS Open …, 2019 - ncbi.nlm.nih.gov
Abstract The African Pharmacogenomics Consortium (APC) was formally launched on the
6th September 2018. This white paper outlines its vision, and objectives towards addressing …

Risk factors for stroke occurrence in a low HIV endemic West African country: a case-control study

FS Sarfo, O Opare-Sem, M Agyei, J Akassi… - Journal of the …, 2018 - Elsevier
Background HIV infection is an emerging vascular risk factor associated with stroke
occurrence. The weight of evidence from sub-Saharan Africa in support of this has accrued …

Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach

SE Kandel, EG Gracey, JN Lampe - Chemical Research in …, 2023 - ACS Publications
Idiosyncratic drug reactions (IDRs) in their most deleterious form can lead to serious medical
complications and potentially fatal events. Nevirapine (NVP), still widely used in developing …

Choice of initial antiretroviral drugs and treatment outcomes among HIV-infected patients in sub-Saharan Africa: systematic review and meta-analysis of observational …

TA Ayele, A Worku, Y Kebede, K Alemu, A Kasim… - Systematic reviews, 2017 - Springer
Background The effectiveness of antiretroviral therapy (ART) depends on the choice of
regimens during initiation. Most evidences from developed countries indicated that there is …

Multicenter study of skin rashes and hepatotoxicity in antiretroviral-naive HIV-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside …

PY Wu, CY Cheng, CE Liu, YC Lee, CJ Yang… - PLoS …, 2017 - journals.plos.org
Objectives Two nucleos (t) ide reverse-transcriptase inhibitors (NRTIs) plus 1 non-NRTI
(nNRTI) remain the preferred or alternative combination antiretroviral therapy (cART) for …

Reasons and risk factors for the initial regimen modification in Chinese treatment-naive patients with HIV infection: A retrospective cohort analysis

J Sun, L Liu, J Shen, T Qi, Z Wang, W Song, R Zhang… - PLoS …, 2015 - journals.plos.org
Background To investigate the reasons and risk factors for modification of the first combined
antiretroviral therapy (cART) currently used for HIV infected patients who were treatment …

Comparative incidence of adverse drug reaction during the first and subsequent year of antiretroviral therapy in a Nigerian HIV infected Cohort

IO Abah, WD Dayom, DA Dangiwa… - African Health …, 2021 - ajol.info
Background: Despite close to two decades of antiretroviral therapy (ART) in Nigeria, data on
late on-onset ART-associated adverse drug reactions (ADRs) are sparse. Objectives: To …

Highlights of the third edition of Chinese guidelines for AIDS diagnosis and treatment (2015)

JJ Sun, HZ Lu - Zhejiang da xue xue bao. Yi xue ban= Journal of …, 2015 - europepmc.org
Abstract 2015 年中华医学会感染病学分会艾滋病学组发布了第三版《 艾滋病诊疗指南》.
新版指南强调抗病毒治疗时点前移: 一旦成人确诊感染人类免疫缺陷病毒 (HIV) …