The nucleolus is the most prominent nuclear substructure assigned to produce ribosomes;
molecular machines that are responsible for carrying out protein synthesis. To meet the …

Homologous recombination (HR) is an evolutionary-conserved mechanism involved in a
subtle balance between genome stability and diversity. HR is a faithful DNA repair pathway …

Replication-transcription collisions shape genomes, influence evolution, and promote
genetic diseases. Although unclear why, head-on transcription (lagging strand genes) is …

DNA damage poses a serious threat to human health and cells therefore continuously
monitor and repair DNA lesions across the genome. Ribosomal DNA is a genomic domain …

The faithful transmission of genetic information to daughter cells is central to maintaining
genomic stability and relies on the accurate and complete duplication of genetic material …

Alterations of the dynamics of DNA replication cause genome instability. These alterations
known as “replication stress” have emerged as a major source of genomic instability in pre …

Designated under the name of chromoanagenesis, the phenomena of chromothripsis,
chromanasynthesis and chromoplexy constitute new types of complex rearrangements …

Most bacterial genes are encoded on the leading strand, co-orienting the movement of the
replication machinery with RNA polymerases. This bias reduces the frequency of detrimental …

Complete duplication of large metazoan chromosomes requires thousands of potential
initiation sites, only a small fraction of which are selected in each cell cycle. Assembly of the …

We previously reported that lagging-strand genes accumulate mutations faster than those
encoded on the leading strand in Bacillus subtilis. Although we proposed that orientation …