The ErbB/HER family of protein-tyrosine kinases and cancer

R Roskoski Jr - Pharmacological research, 2014 - Elsevier
The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

Defects in mitochondrial metabolism and cancer

E Gaude, C Frezza - Cancer & metabolism, 2014 - Springer
Cancer is a heterogeneous set of diseases characterized by different molecular and cellular
features. Over the past decades, researchers have attempted to grasp the complexity of …

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

F Cappello, E Conway de Macario… - Cancer biology & …, 2008 - Taylor & Francis
Hsp60 in eukaryotes is considered typically a mitochondrial chaperone (also called Cpn60)
but in the last few years it has become clear that it also occurs in the cytosol, the cell surface …

Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases

MH Park, MR Jo, YR Kim, CK Lee, JT Hong - Pharmacology & Therapeutics, 2016 - Elsevier
Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to
balance cellular hydrogen peroxide (H 2 O 2) levels, which are essential for cell signaling …

Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets?

AA Khalil, NF Kabapy, SF Deraz, C Smith - Biochimica et Biophysica Acta …, 2011 - Elsevier
Heat shock proteins (HSP) are a family of proteins induced in cells exposed to different
insults. This induction of HSPs allows cells to survive stress conditions. Mammalian HSPs …

Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect

HK Sajja, MP East, H Mao, YA Wang… - Current drug …, 2009 - ingentaconnect.com
Nanotechnology is a multidisciplinary scientific field undergoing explosive development.
Nanometer-sized particles offer novel structural, optical and electronic properties that are not …

Genetic alterations in Krebs cycle and its impact on cancer pathogenesis

K Sajnani, F Islam, RA Smith, V Gopalan, AKY Lam - Biochimie, 2017 - Elsevier
Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and
energy metabolism. Glycolysis in non-oxygen condition is the main energy production …

Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes

A Spreafico, F Chellini, B Frediani… - Journal of Cellular …, 2009 - Wiley Online Library
The aim of the present study was to demonstrate the mitogenic and differentiating properties
of platelet‐rich plasma releasates (PRPr) on human chondrocytes in mono‐and three …

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

F Cappello, A Marino Gammazza… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Hsp60 (Cpn60) assembles into a tetradecamer that interacts with the co-
chaperonin Hsp10 (Cpn10) to assist client polypeptides to fold, but it also has other roles …

HSP-molecular chaperones in cancer biogenesis and tumor therapy: an overview

F Rappa, F Farina, G Zummo, S David… - Anticancer …, 2012 - ar.iiarjournals.org
Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important
class of molecules with various functions. Pathological conditions in which chaperones …