Hyperferritinemia and inflammation

KF Kernan, JA Carcillo - International immunology, 2017 - academic.oup.com
Understanding of ferritin biology has traditionally centered on its role in iron storage and
homeostasis, with low ferritin levels indicative of deficiency and high levels indicative of …

[HTML][HTML] Iron in immune cell function and host defense

D Haschka, A Hoffmann, G Weiss - Seminars in Cell & Developmental …, 2021 - Elsevier
The control over iron availability is crucial under homeostatic conditions and even more in
the case of an infection. This results from diverse properties of iron: first, iron is an important …

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

AA Belaidi, AI Bush - Journal of neurochemistry, 2016 - Wiley Online Library
Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …

Assessment of serum ferritin as a biomarker in COVID-19: bystander or participant? Insights by comparison with other infectious and non-infectious diseases

K Kappert, A Jahić, R Tauber - Biomarkers, 2020 - Taylor & Francis
Background The 2019 coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus
has an impact on all aspects of patient care. Serum ferritin generally represents a biomarker …

[HTML][HTML] The role of iron homeostasis in remodeling immune function and regulating inflammatory disease

Q Mu, L Chen, X Gao, S Shen, W Sheng, J Min, F Wang - Science Bulletin, 2021 - Elsevier
The essential trace element iron regulates a wide range of biological processes in virtually
all living organisms. Because both iron deficiency and iron overload can lead to various …

The ferritins: molecular properties, iron storage function and cellular regulation

PM Harrison, P Arosio - Biochimica et biophysica acta (BBA)-bioenergetics, 1996 - Elsevier
The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester
the element gives ferritin the dual functions of iron detoxification and iron reserve. The …

Ferritin–from iron, through inflammation and autoimmunity, to COVID-19

N Mahroum, A Alghory, Z Kiyak, A Alwani, R Seida… - Journal of …, 2022 - Elsevier
While it took decades to arrive to a conclusion that ferritin is more than an indicator of iron
storage level, it took a short period of time through the COVID-19 pandemic to wonder what …

[HTML][HTML] Iron biology in immune function, muscle metabolism and neuronal functioning

JL Beard - The Journal of nutrition, 2001 - Elsevier
The estimated prevalence of iron deficiency in the world suggests that there should be
widespread negative consequences of this nutrient deficiency in both developed and …

Obesity and iron deficiency: a quantitative meta‐analysis

L Zhao, X Zhang, Y Shen, X Fang, Y Wang… - Obesity …, 2015 - Wiley Online Library
Hypoferraemia (ie iron deficiency) was initially reported among obese individuals several
decades ago; however, whether obesity and iron deficiency are correlated remains unclear …

Regulation of ferritin genes and protein

FM Torti, SV Torti - Blood, The Journal of the American Society …, 2002 - ashpublications.org
Increasingly, perturbations in cellular iron and ferritin are emerging as an important element
in the pathogenesis of disease. These changes in ferritin are important not only in the classic …