Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps
of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …

Exosomes represent a subtype of extracellular vesicle that is released through retrograde
transport and fusion of multivesicular bodies with the plasma membrane. Although no …

Purpose: Identification of clinically actionable molecular subtypes of pancreatic ductal
adenocarcinoma (PDAC) is key to improving patient outcome. Intertumoral metabolic …

In the present study, we discuss the recent developments in oxysterol research. Exciting
results have been reported relating to the involvement of oxysterols in the fields of …

Increasing evidence suggests that induction of lethal macroautophagy/autophagy carries
potential significance for the treatment of glioblastoma (GBM). In continuation of previous …

Autophagy has important functions in maintaining energy metabolism under conditions of
starvation and to alleviate stress by removal of damaged and potentially harmful cellular …

Every cell in vertebrates possesses the machinery to synthesise cholesterol and to
metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile …

Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

Simple Summary Melanoma is a devastating skin cancer characterized by an impressive
metabolic plasticity. Melanoma cells are able to adapt to the tumor microenvironment by …