Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …

Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …

Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox
signaling. Here, contributions of redox cycling and alkylating properties of quinones (both …

Defects in intestinal epithelial tight junctions (TJs) allow paracellular permeation of noxious
luminal antigens and are important pathogenic factors in inflammatory bowel disease (IBD) …

Emerging contaminants, as a group of trace contaminants arising from pharmaceuticals,
personal care products, etc., are of growing concern due to their potential hazard to the …

Acrylamide is a well characterized neurotoxicant known to cause neuropathy and
encephalopathy in humans and experimental animals. To investigate the role of nuclear …

Butylated hydroxyanisole (BHA) is an antioxidant and class-2B carcinogen. It is
biotransformed to tert-butylhydroquinone (TBHQ), which readily auto-oxidizes to the …

Included among the many environmental electrophiles are aromatic hydrocarbon quinones
formed during combustion of gasoline, crotonaldehyde in tobacco smoke, methylmercury …