Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling
hub that senses and integrates environmental and intracellular nutrient and growth factor …

Aging is associated with the development of disease. Periodontal disease is one of the
many diseases and conditions that increase in prevalence with age. In addition to the …

Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo
pathogenesis is largely unclear. Here, we generated a p16-Cre ERT2-tdTomato mouse …

Autophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular
metabolic demands by removal of the damaged molecules and organelles and for …